Na Nue Hotel is in the Phạm Ngũ Lão area of District 1, the central district of Ho Chi Minh City, where small hotels, cafés and restaurants fill the streets. The hotel is set back in a quiet alley, and Chùa An Lạc, a small pagoda, is 50 m away, with September 23 Park 100 m further on. Several cafés and restaurants are within 50 m, among them the Vietnamese restaurant Nhà Hàng Hương Việt Vietnamese Aroma.
Ben Thanh metro station, 500 m away, is the start of Metro Line 1, and Saigon Railway Station is 2.3 km away. Tan Son Nhat International Airport is 5.5 km from the hotel, and a shuttle runs there for a fee. The hotel has no parking, so arrive by taxi or ride-hailing car. The two bus stations, Bến xe buýt Sài Gòn and Bến xe Sài Gòn, are 450 m and 500 m away.
Ben Thanh Market, 650 m away, is a covered market for food, clothing and souvenirs, and Independence Palace is 950 m off. The Ho Chi Minh City Fine Arts Museum is 600 m away, Tao Dan Park 650 m, the Museum of Ho Chi Minh City 1 km and the War Remnants Museum 1.2 km. Bùi Viện street, the backpacker street with bars and restaurants, is close by for the evening, and Nha Rong Wharf lies 1.4 km away.